Expression of early growth response gene-1 mRNA in esophageal carcinoma tissue and its relationship with the survival time of the patients with esophageal carcinoma
- VernacularTitle:食管癌组织早期生长反应基因-1mRNA表达与患者生存期关系的研究
- Author:
Xiaobin LI
;
Dingzhu FANG
;
Weixing GUI
;
Jun ZHANG
;
Binsheng XIE
;
Dabing WANG
- Publication Type:Journal Article
- Keywords:
Esophageal tumor;
Early growth response gene-1 mRNA;
Survival time;
Prognosis
- From:
Clinical Medicine of China
2008;24(6):524-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of early growth response gene-1(Egr-1)in esophageal carcinoma tissue,and to explore the relationship between Egr-1 and the survival time of the patients with esophageal carcinoma.Methods RT-PCR was performed to detect the expression of Egr-1 mRNA in68 cases of esophageal carcinoma.The relationship between survival time and prognosis was analyzed.Results The expression of Egr-1 mRNA was the lowest(0.567±0.404),(0.945±0.336)and(1.201±0.347)in esophageal carcinoma tissue,para-cancerous tissue and normal esophageal mucosa tissue,respectively(F=12.709,P＜0.05,P＜0.00).21 cases showed the positive expression of Egr-1 mRNA of both the esophageal carcinoma tissue and the para-cancerous tissue.21 cases showed the positive expression of Egr-1 mRNA in a single esophageal carcinoma tissue or the para-cancerous tissue.26 cases showed the negative expression of Egr-1 mRNA both in the esophageal carcinoma tissue and the paracancerous tissue.The positive rate of Egr-1mRNA expression was 65.71%and 30.00%in the groups of the survival time for three years and the groups of the survival time for one year(P＜0.05).The survival rates in the two groups with positive expression of Egr-1 mRNA were 94.44%and 86.96%,respectively(P＞0.05).Conclusion Decreased level of EGR1 expression may be related to esophageal carcinogenesis.The expression level of Egr-1 mRNA might be associated with the survival time of the patients with esophageal carcinoma.Egr-1 expression in esophageal carcinoma tissue may be of great value for determining prognosis of esophageal carcinoma.
