Increased expressions of IL-6 and its receptor gp130 in the thyroid tissues of patients with Graves' disease
- VernacularTitle:Graves病患者甲状腺组织内IL-6及gp130表达增强
- Author:
Dongdong MENG
;
Zhihong LIAO
;
Liang ZHENG
;
Weiming Lü
;
Xiaoxi LI
;
Caisheng YE
;
Yibin XIAO
;
Minsheng YUAN
- Publication Type:Journal Article
- Keywords:
Graves' disease;
Interleukin-6;
Recepor;
intefleukin-6;
Thyroid tissue
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(3):306-307
- CountryChina
- Language:Chinese
-
Abstract:
Expressions of interleukin-6 (IL-6) and its receptor (gp80、gp130) in 8 patients with Graves' disease (GD) were compared with those in 8 euthyroid patients with nodular goiter or benign thyroid adenoma. The thyroid tissues of GD expressed significantly higher IL-6 mRNA, gp130 mRNA and IL-6 protein than those of the control group, suggesting that activated IL-6/gp130 signal pathway in the thyroid tissue may contribute to the pathogenesis of GD.
