Regulative effect of complement factor H and adrenomedullin on HBZY-1 rat mesangial cells cultured under high glucose concentration
- VernacularTitle:补体因子H和肾上腺髓质素对高糖培养的HBZY-1大鼠系膜细胞的调节作用
- Author:
Houfa GENG
;
Yibing LU
;
Xiuqin JIANG
;
Huimin LI
;
Jing XU
;
Heng MIAO
- Publication Type:Journal Article
- Keywords:
Complement factor H;
Adrenomedullin;
Diabetes mellitus
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(3):319-321
- CountryChina
- Language:Chinese
-
Abstract:
The renal protective effect of complement factor H(CFH)and adrenomedullin (AM) on rat mesengial ceils (HBZY-1) cultured under high glucose levels was investigated. Results indicated that AM and CFH inhibited the expressions of transforming growth factor-β1 and extracellular matrix in HBZY-1 cells, suggesting that CFH and AM in combination seem to show some renal protective effects on diabetic nephropathy.
