The expression, and significance of PTA1 in patients with pregnancy-indnced hypertension syndrome
- VernacularTitle:妊娠高血压综合征患者血小板/T红细胞活化抗原1的表达及意义
- Author:
Ruihuan SU
;
Changzheng LIAO
;
Xuenian YIN
;
Sizhu CHEN
;
Wenli XU
;
Kang LI
- Publication Type:Journal Article
- Keywords:
Gestosis,EPH;
Platelet activating factor;
E selectin;
Flow cytometry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(7):1067-1069
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of the expression, regulation and adhesion of PTA1 in pregnancy induced hypertension(PIH). Methods The expression,regulation and adhesion of PTA1 on vascular en- dothelial cells incubated by sera from 10 PIH patients and 10 normal pregnant women repectively was detected by flow cytometry. Results The positive rate of PTA1 15.51% (24h) and 6.32 % (48h) in PIH group is significantly higher than that 7.81% (24h) and 4.72 % (48h) in normal pregnant woman group( P < 0.01 ). After the incubation with platelets,the positive rate of PTA1 6.64% (24h) and 4.13% (48h) in PIH group is lower than before(P< 0.05). The PTA1 expression 8.11% (24h) and 4.28% (48h) in PIH group is much lower after blocking with PTA1/IgG than that before(P < 0.01 ). Conclusion There are some abnormal stimulated factors in PIH patients, which activate vascular endothelial cells. PTA1 plays an important role in the adhesion of platelets to vascular en- dothelial cells, PTA1 is closely related to the progress of PIH which indicates that PTA1 directly or indirectly takes part in the pathophysiologic consequences of PIH.
