The correlation between myocardial microcirculation and inflammation in acute myocardial infarction
- VernacularTitle:急性心肌梗死后心肌微循环障碍与炎症反应的关系
- Author:
Lanfeng WANG
;
Chunhong XIU
;
Dan LI
;
Zujin WANG
;
Xue JIANG
;
Huan WANG
;
Qing TANG
;
Zhonghua WANG
;
Yupeng HUANG
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Microbubbles;
Myocardial infarction;
Inflammation
- From:
Chinese Journal of Ultrasonography
2008;17(8):672-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between myocardial microcirculation and inflammation in acute myocardial infarction(AMI)by myocardial contrast echocardiography(MCE).Methods Eighty-one AMI patients(AMI group)and 30 healthy adults(normal control group)were enrolled.White blood cell(WBC),hypersensitive C reactive protein(hsCRP)and neutrophilic gtanulocyte percentage(G%)were measured in patients and healthy adults.According to different count of WBC,AMI group was devided into A group(n=40,WBC≥10×109/L)and B group(n=41,WBC＜10×109/L).Myocardial contrast intensity(A),blood flow rate(β)and myocardial blood volume(MBF=A×β)of each segment were measured by MCE during 5-7 days of hospitalization.Results Compared with control group.WBC,hsCRP in A group and hsCRP in B group were significantly elevated(P＜0.05).A,β and MBF in A group were significantly lower than those in B group(P＜0.05).WBC and hsCRP in A group had significant negative correlations with β respectively(BWBC=-0.67,P＜0.05;BhsCRP=-0.5 1,P＜0.05).Conclusions The level of plasma inflammatory factors were remarkably increased after AMI,which had a positive correlation with low microcirculation perfusion.
