Changes of soluble interleukin-2 receptor and high sensitivity C-reactive protein in renal allograft recipients
- VernacularTitle:肾移植受者血清可溶性白介素-2受体和超敏C反应蛋白变化研究
- Author:
Lianzhou CHEN
;
Dong WANG
;
Changxi WANG
;
Wentao ZENG
;
Wen LI
;
Qian WANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Receptors,interleukin-2;
C-reactive protein;
Graft rejection
- From:
Journal of Chinese Physician
2008;10(10):1346-1347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of soluble interleukin-2 receptor(slL-2R) and high sensitivity C-reactive (hs-CRP) protein in renal allograft recipients and its relationship with rejective response of renal allograft. Methods The concentration of sIL-2R and hs-CRP were detected in 91 patients with renal allograft recipients and 100 health controls. CRP was measured by particle enhanced immuo-turbidimetric method, sIL-2R was detected by ELISA. Results The concentration of sIL-2R and hs-CRP in the recipients with acute rejec-tion was significantly higher than those without graft rejection and health controls. The concentration of hs-CRP in the recipients with chronic rejection was higher than those without graft rejection and health controls. There was no evidence of significant changes in the concentration of sIL-2R and hs-CRP between the health control group and the recipients without graft rejection. Conclusion slL-2R and hs-CRP might play an important role in graft rejection. The measurement of sIL-2R and hs-CRP is important for the diagnosis of graft rejection.
