DNA flow cytometry in pheochromocytoma and paraganglioma.
10.3349/ymj.1992.33.3.249
- Author:
Woo Hee JUNG
1
;
Woo Ick YANG
;
Chanil PARK
;
In Joon CHOI
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Adrenal gland;
pheochromocytoma;
paraganglioma;
flow cytometry;
DNA content;
histopathology
- MeSH:
Adolescent;
Adrenal Gland Neoplasms/*genetics/pathology;
Adult;
Age Factors;
Child;
DNA, Neoplasm/*analysis;
Female;
*Flow Cytometry;
Human;
Male;
Middle Age;
Mitosis;
Paraganglioma/*genetics/pathology;
Pheochromocytoma/*genetics/pathology;
Ploidies
- From:Yonsei Medical Journal
1992;33(3):249-257
- CountryRepublic of Korea
- Language:English
-
Abstract:
Flow cytometric DNA analysis was performed on 19 adrenal pheochromocytomas and 6 extra-adrenal paragangliomas in parallel with clinical and histopathological review to determine the usefulness of this technique to predict biologic behavior of these tumors. In pheochromocytomas and paragangliomas, tetraploidy or near-tetraploidy occurred in 32% and 33% and aneuploidy in 10% and none respectively. A case of malignant pheochromocytoma had diploid DNA content. Occurrence of aneuploidy or tetraploidy is frequent in clinically benign tumors in conjunction with a marked degree of nuclear atypia and cannot be a predictor of malignancy.
