Study of proton magnetic resonance spectroscopy of hippocampus in non - demented Parkinson's disease patients
- VernacularTitle:非痴呆性帕金森病患者海马质子磁共振波谱研究
- Author:
Haidong HUANG
;
Chunmin YANG
;
Yan QU
;
Kai ZHAO
;
Jianwen GU
;
Hui ZHANG
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Magnetic resonance spectroscopy;
Hippocampus
- From:
Clinical Medicine of China
2008;24(12):1185-1188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical application value of proton magnetic resonance spectroscopy (1H-MRS) in the metabolism of the hippocampus in non-demented Parkinson's disease(PD) patients. Methods 1H-MRS localized to both hippocampus,was carried out in 36 non-demented PD (14 patients with Hoehn-Yahr stage Ⅰ,8 patients with Hoehn-Yahr stage Ⅱ,8 patients with Hoehn-Yahr stage Ⅲ ,and 6 patients with Hoehn-Yahr stage Ⅳ) and 20 age-matched healthy control subjects. The metabolite ratios of N-acetylasparatate (NAA)/creatine (Cr),and choline-containing compounds (Cho)/Cr in PD patients were compared with those in the age-matched healthy control subjects. Results NAA/Cr ratios were reduced significantly and Cho/Cr ratios were increased sig-nificantly in both hippocampus of patients with Hoehn-Yahr stage Ⅳ compared to those in the age-matched healthy control subjects (P<0.05). However,no significant differences in NAA/Cr and Cho/Cr ratios were found between patients with Hoehn-Yahr stage Ⅰ-Ⅲ and the age-matched healthy control subjects (P>0.05). Conclusion 1H-MRS can provide the metabolic information ,and reflect the pathological changes of nerve cell in the hippocampus of non-demented PD patients with Hoehn-Yahr stage Ⅳ. It is helpful to predict the risk of dementia in PD.
