Progress in the study of molecular mechanisms in thyroid hormone insensitive syndrome
- VernacularTitle:甲状腺激素不敏感综合征分子机制的研究进展
- Author:
Jingfang LIU
;
Bingyin SHI
- Publication Type:Journal Article
- Keywords:
Thyroid hormones;
Receptors,thyroid hormone;
Thyroid hormone resistance syndrome;
Metabolism;
Deiodinase(Chin J Endocrinol Metab,2008,24:683-685)
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(6):683-685
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid hormone insensitive syndrome is an inherited disease characterized by decreased target tissue responsiveness to thyroid hormone. Most cases are due to thyroid hormone receptor β gene mutation. Two novel types of thyroid hormone insensitive syndrome were recently identified, which are caused by gene mutations of MCT8, a specific thyroid hormone transporter, and SBP2 in the synthesis of deiodinase.
