Predicting value of plasma homocysteine concentrations for diabetic retinopathy

VernacularTitle:血浆同型半胱氨酸水平对糖尿病视网膜病变的预测意义
Author: Jianbo LI ; Yuze CHENG ; Qing DAI ; Yu ZHANG ; Yanjuan WANG ; Jiwen CHEN ; Keqin ZHANG ; Chao LIU
Publication Type:Journal Article
Keywords: Cysteine; Diabetic refinopathy; Risk factors
From: Chinese Journal of Postgraduates of Medicine 2009;32(3):6-8
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between plasma homocysteine levels and diabetic retinopathy (DR).MethodIn 40 DR patients and 63 non-DR patients,the indexes including plasma homocysteine concentrations,duration of diabetes,ages,blood pressure,preprandial blood glucose(PBG),plasma GHbA,e,plasma lipids,serum folie acid and semm vitamin B12 were analyzed.ResultsPlasma homocysteine level was significantly higher in DR patients (12.9μmol/L) than that in non-DR patients (7.8μ.mol/L) (P＜0.01),and the relationship remained significant correlation after adjusted for duration of diabetes,GHbA1c,ages,serum folic acid and serum vitamin B12(OR = 1.23,P＜0.05).ConclusionHyperhomocysteinimia is a risk factor and an independent predieator of DR.