Effect of low-dose harringtonine and cytarabine in combination with granulocyte colony-stimulating factor on elderly patients with acute myelogenous leukemia

VernacularTitle:小剂量三尖杉酯碱和阿糖胞苷联合粒细胞集落刺激因子治疗老年急性髓细胞白血病疗效观察
Author: Feiheng CHEN ; Yongzhong SU ; Yuanshen LIU ; Chunlan ZHUANG ; Huijun LI
Publication Type:Journal Article
Keywords: Leukemia,myelocytic,acute; Harringtonine; Cytarabine; Granulocyte colony-stimunating factor; Aged
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(2):247-248
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy and toxicity for the protocol of low-dose harringtonine and cytarabine(HA regimen)in combination with granulocyte colony-stimulating factor(G-CSF)in elderly patients with acute myelogenous leukemia(AML).Methods Thirty-five AML patients were treated with HAG including low-dose chieved PR.The overall response rate was 83%.5 of 35(14%)was non-remiasion.Two patients died in the duration of treatment.The main complication of chemotherapy is myelosuppresion.Conclusion Low-dose HA regimen in combination with G-CSF is effective and safe in elderly patients with AML.