Intraperitoneal hyperthermal chemotherapy combined with general chemotherapy after surgery for malignant gastrointestinal tumors
10.3760/cma.j.issn.1671-7368.2009.03.019
- VernacularTitle:胃肠道恶性肿瘤术后腹腔热灌注联合全身化疗的疗效观察
- Author:
Junli CAO
;
Zonglan HU
;
Zhanzhao FU
;
Tao GU
;
Shaohui CHENG
;
Haixia HUA
;
Sen YANG
;
Lijiao ZHANG
;
Yanhong YANG
;
Lixin DONG
- Publication Type:Journal Article
- Keywords:
Gastrointestinal neoplasms;
Chemotherapy,cancer,regional perfusion
- From:
Chinese Journal of General Practitioners
2009;8(3):185-186
- CountryChina
- Language:Chinese
-
Abstract:
A total of 101 patients undergoing operations for malignant gastrointestinal tumors (stage Ⅱ to Ⅲ) were enrolled and randomly assigned to receive intraperitoneal hyperthermal chemotherapy plus intravenous chemical injection (treatment group, n=51) or routine intravenous chemical injection (control group, n=50). Our results indicated that the recurrence rate and the metastatic rate in the treatment group were significantly lower than those in the control group (25.5% vs. 50.0%, 13.7% vs. 30.0%, both P< 0. 05), although the 3-and 5 year-survival rates were significantly higher (both P < 0. 05). Our data suggest that intraperitaneal hyperthermal chemotherapy plus general chemotherapy after surgery for malignant gastrointestinal tumors could effectively reduce tumor recurrence and metastases and improve long-term survival.
