Influence of Rhubarb on Renal Expression of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Diabetes Mellitus Rats

VernacularTitle:大黄对糖尿病大鼠肾脏ICAM-1及VCAM-1表达的影响
Author: Fengsheng TIAN ; Wendong LI ; Hongbo DUAN ; Xiuhai SU ; Xiaoyun WANG
Publication Type:Journal Article
Keywords: Rhubarb. Diabetic model; ICAM-1; VCAM-1
From: International Journal of Traditional Chinese Medicine 2009;31(2):105-106
CountryChina
Language:Chinese
Abstract: Objective To explore the influence of DaHuang on renal expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in diabetes mellitus rats. Methods After the DM rat model was made, 24 DM rats were selected randomly and divided into a model group (12 DM rats) and a Rhubarb group group were given pure water in equal amount every day. 8 weeks later, kidney was cut to make pathological slice and method of SP immunohistochemistry was adopted for staining. Observed the expression of ICAM-1 and VCAM-1. Result The renal expression of ICAM-1 and VCAM-1 in the rhubarb group and the model group were obviously increased compared with the normal group (P<0.05). The renal expression of ICAM-1 and VCAM-1 in the rhubarb group was obviously weaker than the normal group(P<0.05). Conclusion Rhubarb could obviously inhibit the renal expression of ICAM-1 and VCAM-1 in diabetes mellitus rats and protect kidney of diabetes mellitus rats.