Protein Z, protein Z-dependent protease inhibitor and stroke
10.3760/cma.j.issn.1673-4165.2009.03.015
- VernacularTitle:蛋白质Z、蛋白质Z依赖性蛋白酶抑制物与卒中
- Author:
Yinong CHEN
;
Zhaohu CHU
- Publication Type:Journal Article
- Keywords:
protein Z;
protein Z-dependent protease inhibitor;
stroke
- From:
International Journal of Cerebrovascular Diseases
2009;17(3):229-232
- CountryChina
- Language:Chinese
-
Abstract:
Protein Z (PZ) is a vitamin K-dependent protein. As a cofactor for the protein Z-dependent protease inhibitor (ZPI), it inhibits coagulation factor X under the existence of phospholipid and calcium ion, and increases the ZPI activity by nearly 1000-fold, thus it plays a role in the process of thrombosis. ZPI inhibits coagulation factor Ⅺ a alone. ZPI activity is also consumed in the process of inhabiting factor Ⅹa and Ⅺa. This article reviews the biological characteristics of PZ and ZPI and their association with stroke.
