Effect of irradiation on EGFR nuclear translocation in cervical carcinoma cell lines
10.3760/cma.j.issn.0254-5098.2009.02.003
- VernacularTitle:辐射对宫颈癌细胞EGFR核转运的影响
- Author:
Shiying YU
;
Bo LUO
;
Liang ZHUANG
;
Shu XIA
;
Zhen ZHAO
;
Lei RONG
- Publication Type:Journal Article
- Keywords:
EGFR;
Cervical carcinoma;
Radiosensitivity
- From:
Chinese Journal of Radiological Medicine and Protection
2009;29(2):133-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the EGFR nuclear translocation in cervical carcinoma cell lines after irradiation and its possible role in radiation tolerance.Methods Western blotting was used to detect the nuclear EGFR and cytoplastic EGFR after irradiation.The effect of Cetuximab on expression of nuclear EGFR and survival fractions were investigated.Results After irradiation,compared with control group,the expression of nuclear EGFR protein increased in irradiated cervical carcinoma cell.Cetuximab inhibited the radiation-induced nuclear EGFR expression with decreased survival fractions.Conclusion Radiation could induce EGFR nuclear translocation in cervical carcinoma cell lines and nuclear EGFR might be correlated with radiation tolerance in Cervical carcinoma cell.
