Study on the serum organochlorine pesticides residues levels in breast cancer patients with different estrogen receptor
10.3760/cma.j.issn.1008-6315.2009.05.033
- VernacularTitle:不同雌激素受体状态乳腺癌患者血清有机氯农药残留物水平研究
- Author:
Ming LI
;
Dongliang SUN
;
Ruiwei LI
;
Weiguo XU
;
Guiru FU
;
Shulan LIU
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Estrogen receptor;
Hexachlorocyclohexane;
Dichloro-diphenyl-trichloro-ethane
- From:
Clinical Medicine of China
2009;25(5):534-537
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the serum organochlorine pesticides residues levels in breast cancer pa-tients with different estrogen receptor(ER). Methods 93 patients of breast cancer from Fengnan districtand 65 pa-tients from Tanghai county in Tangshan were selected,whose ER were detected by pathology and serum organochlo-fine pesticides (DDTs and HCHs) levels were detected and compared with gas chromatography/electron capture. Results The orders of detection rate of HCH isomer in breast cancer patients in two areas were β-HCH >δ-HCH > α-HCH >γ-HCH. The orders of detection rate of DDT isomer in breast cancer patients in two areas were PP'-DDE > PP'-DDT > OP'-DDT > PP'-DDD. The serum levels of β-HCH, PP'-DDE in breast cancer patients in two are-as were positively correlated with age (r=0.272 ,0.330 , P<0.01) or BMI (r=0.312,0.187, P <0.01, <0.05). There were statistical differences in the serum β-HCH,δ-HCH,PP'-DDE levels between the estrogen receptor posi-tive breast cancer patients and the estrogen receptor negative breast cancer patients in two areas (P<0.05 for each). Conclusion The serum organochlorine pesticides residues levels in breast cancer patients with positive es-trogen receptor are higher than that with negative estrogen receptor, implicating that breast cancer is dependent on es-trogen. The cause of breast cancer is likely due to estrogen-like effect of serum organochlorine pesticides residues.
