Colorectal high grade malignancy adenorarcinoma
10.3760/cma.j.issn.1007-631X.2009.05.009
- VernacularTitle:结直肠高度恶性腺癌的临床病理特点和预后分析
- Author:
Xu CHE
;
Zhixiang ZHOU
;
Yi SHAN
;
Chengfeng WANG
;
Dongbing ZHAO
;
Yantao TIAN
;
Ping ZHAO
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Carcinoma,signet-ring cell;
Mueinous carcinoma;
Pathology,surgical;
prognosis
- From:
Chinese Journal of General Surgery
2009;24(5):377-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinieopathologieal features and prognosis in a high grade malignancy group of colorectal mueinous carcinoma, signet-ring cell carcinoma and low-differentiated carcinoma. Methods Retrospective analysis and follow-up were made on 148 patients with colorectal mucinous carcinoma, 55 patients with signet-ring cell carcinoma and 281 low- differentiated carcinoma treated in our hospital from 1988 to 2006. Obtained data were analyzed by SPSS13.0. Related factors underwent x2 analysis, survival analysis were estimated using Kaplan-Meier method and compared using the Log-rank test. Results Coloreetal signet-ring cell carcinoma were significantly different from mucinous carcinoma and low- differentiated carcinoma in gender, age, tumor location, bowel obstruction, operative modus, tumor embolism, tumor infiltration and lymph node metastasis(x2 = 7, 67,38.4,86.0,14.5,93.7,17.3,62. 1,24. 4,56.17 ,P <0.05). Median survival time was 24 months in signet-ring cell carcinoma, 47 months in mueinous carcinoma and 49 months in low- differentiated carcinoma. The difference is of significance(x2 = 21.3, P < 0.05). Conclusions Clinicopathological characteristics and prognosis of colorectal signet-ring cell carcinoma, mueinous carcinoma and low- differentiated carcinoma is of significant difference(P < 0.05). Malignancy of signet-ring cell carcinoma is higher with worse prognosis.
