Effect of pulmonary surfactant on the incidence of bronchopulmonary dysplasia
10.3760/cma.j.issn.1671-0282.2009.06.009
- VernacularTitle:肺表面活性物质替代治疗与支气管肺发育不良的关系
- Author:
Xiuzhen YE
;
Jie YANG
;
Jieling WU
;
Qundi DENG
;
Chuan NIE
;
Wencheng LI
;
Yue WANG
- Publication Type:Journal Article
- Keywords:
Surfactant;
Hyaline membrane disease;
Bronchopulmonary dysplasia;
Infant,Premature
- From:
Chinese Journal of Emergency Medicine
2009;18(6):584-587
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore, the effect of different dosage of pulmonary surfactant (PS) on the inci-dence of bronchopulmanary dysplasia. Method Four hundred and three premature infants with hyaline membrane disease were divided into 3 groups according to the dose of PS: low-dose group (L-PS group, ≤ 100 mg/kg, n =188) ,high-dose group(H-PS group, > 100 mg/kg, n = 94) and no-PS group (N-PS group, n = 121). The frac-tional inspired oxygen(FiO2) and ptlmonary oxygenating function before and after 6 hours treatment were observed and the durations of oxygen therapy and mechanical ventilation, frequency of repeated intubafion, length of hospi-talization and the incidence of BPD were compared among the three groups. Results After 6 hours PS administra-tion, the FiO2,oxygen index and duration of oxygen therapy and mechanical ventilation were significantly decreased (P <0.05), while PO2 and the arterio-alveolar partial pressure of oxygen were significantly increased (P <0.05)in the H-PS and L-PS groups, compared with the N-PS group. Compared with the L-PS and N-PS groups,the H-PS group showed a decreased incidence of BPD. Conclusions PS administration could improve the pul-monary oxygenation and prevent the development of BPD, especially in high-dose.
