Effect of globular adiponectin on the function of NIT-I cells under high glucose medium
10.3760/cma.j.issn.1000-6699.2009.03.023
- VernacularTitle:球型脂联素对高糖环境NIT-1胰岛β细胞功能的影响
- Author:
Jia ZHOU
;
Yan LI
;
Chuan YANG
;
Mingtong XU
;
Fangping LI
;
Li YAN
;
Hua CHENG
;
Zuzhi FU
- Publication Type:Journal Article
- Keywords:
NIT-I cell lines;
Global adiponectin;
NAD(P) H oxidase
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(3):316-317
- CountryChina
- Language:Chinese
-
Abstract:
The effect of globular adiponectiin (gAd)on the function of NIT-1 cells under high glucose medium was investigated. The results showed that gad could completely block the increase of NADPH oxidase components p47phox expression and recover mRNA expression of pancreatic duodenal homeobox-I ,paired box gene 6,glucose transpoter 2,and glucokinase except neurogenic differentiation factor 1 (P<0.05 or P<0.01). Whereas,impaired insulin secretion and mRNA expression at high glucose concentration were not significantly improved by gAd.
