Relationship between the prevalence of hyperuricemia and thyroid dysfunction

VernacularTitle:高尿酸血症与甲状腺功能异常关系的相关性研究
Author: Yushan MA ; Zhimin LIU ; Xia WANG ; Changxi CHEN ; Tong HUANG ; Zhongli HONG
Publication Type:Journal Article
Keywords: Hyperuricemia; Thyrotropin; Thyroid diseases; Epidemiology
From: Chinese Journal of Rheumatology 2009;13(8):528-530
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between the prevalence of hyperuricemia and thyroid dysfunction. Methods 10 405 active and retired workers aged 21 to 89 years in a Petrochemical Corporation in Ningho area of Zhejiang Province were included. Serum thyroid-stimulation hormone (TSH), free thyroxine thyroid diseases, the prevalence of thyroid dysfunction was 4.2%, 2.9% in male and 7.2% in female. The percentage of subjects with low TSH concentration was 0.4% in male and 0.9% in female,the percentage of TSH subjects,the serum uric acid was significantly increased in subjects with high TSH (P<0.05) and not an independent factor associated with hyperuricemia (OR=1.61 for male and 1.72 for female, P value was less than 0.01 for both). Conclusion The prevalence of hyperuricemia is significantly associated with increased TSH concentration. Overt or subclinical hypothyroidism may be risk factors for hyperuricemia.