The protective effect of propofol on pulmonary ischemia/reperfusion injury
- VernacularTitle:异丙酚对大鼠肺缺血/再灌注损伤的保护作用
- Author:
Suobei LI
;
Wei RUAN
;
Junmei XU
;
Yan LI
;
Zhiping LV
- Publication Type:Journal Article
- Keywords:
PropofoL/PD;
Lung/BS/PP/DE;
Ischemia/PC;
Reperfusion injury/PC
- From:
Journal of Chinese Physician
2009;11(9):1186-1188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of propofol against ischemia/reperfusion injury in rat lung. Methods Rat model of pulmonary ischemia/reperfusion injury was used in this study. Rats were randomly divided into three groups, including sham opera-tion group (group A), iachemia/reperfusion group (group B) and propofol group (group C), 15 rats in each group. The concentration of tumor necrosis factor -α and interleukin-6 in bronchoalveolar lavage fluid (BALF) were measured by enzyme linked immunosorbent assay (ELISA). Then blood gas analysis, lung wet/dry (W/D) weight ratio were detected in each group. Results Propofol could significantly improve PaO2, reduce the W/D value and the contents of TNF-α and IL-6 in BALF. Conclusion Propofol effectively suppressed the pro-duction and release of inflammatory cytokine, therefore it can protect the lung from isehemia/reperfusion injury.
