Shenfu injection in the treatment of severe acute pancreatitis
10.3760/cma.j.issn.1674-1935.2009.05.001
- VernacularTitle:参附注射液治疗重症急性胰腺炎的临床研究
- Author:
Zhongdong ZOU
;
Zaizhong ZHANG
;
Lie WANG
;
Shaoquan CHEN
;
Lijun TANG
;
Xiaohuang TU
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
acute necrotizing;
Shenfu injection;
Cytokines;
Microcirculation
- From:
Chinese Journal of Pancreatology
2009;9(5):291-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy,safety and the possible mechanism of shenfu injection (SFI)in the treatment of severe acute pancreatitis(SAP).Methods A total of fifty-eiSht patients with SAP admitted to Research Institute of General Surgery of Nanjing Military Command from June 2006 to September 2008 were randomized into the conventional group(n=28)and SFI group(n=30).Patients in SFI group were treated by plus SFI(50 ml per day for 7 days)on routine treatment.The time to pain ease,bowel sound recovery times,body temperature recovery time were observed;APACHE Ⅱ score,Binder point was calculated;serum amylase,TNF-α and IL-1β were measured.The complication rate,operation rate,mortality were analyzed.Results The duration of abdominal pain,recovery of bowel sound,body temperature,and mean hospital stay days in SFI group were 95.3±2.8)d,(5.1±1.7)d,(7.1±2.4)d and(32.4±6.4)d;7 days later the APACHE Ⅱ score,Binder point was 8.63±1.33 and 6.50±1.66.respectively;the serum levels of amylase,TNF-α,and IL-1β were(1152±576)U/L,(48.7±16.4)ns/na and(199.3±53.3)ng/ml,respectively.12 episodes of severe complication occurred,operation rate was 3.33%(4/30)and the mortality rate was 0%.All the parameters were statistically significantly lower than those in the conventional group(P＜0.05 or P＜0.01).There was no adverse event related to SFI.Conclusions SFI was safe and effective for SAP,and the mechanism may be related to inhibit over-release of inflammatory medium and cytokines,and improve microcirculation.
