Effect of interleukin-22 on cell signaling pathways
10.3760/cma.j.issn.1673-4203.2009.12.022
- VernacularTitle:白细胞介素-22对细胞信号转导通路的影响
- Author:
Xuanhao LI
;
Lindong DU
- Publication Type:Journal Article
- Keywords:
interleukin-22;
signaling pathways;
cell proliferation;
cell apoptosis
- From:
International Journal of Surgery
2009;36(12):849-852
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-22 (IL-22) is a new kind of eytokine discovered in 2000. The major sources of IL-22 are activated T1 -cells and NK-cells. Tissue cells at outer body barriers, i.e. of the skin, kidney, the di-gestive and respiratory systems all highly express IL-22R or respond to IL-22. IL-22 functions by promoting the anti-microbial defense, inducing phase reactants, protecting against damage and enhancing natural immu-nity. Furthermore, IL-22 mediates the proliferation, differentiation and apoptesis in cancer cells, that gives us a new idea about tumor therapy.
