Expression of cytokeratin19 mRNA and integrin alpha v beta 3 in breast cancer patients with negative axillary lymph nodes

VernacularTitle:淋巴结阴性乳腺癌患者细胞角蛋白19 mRNA与整合素α_vβ_3表达的相关性研究
Author: Longzhou CHEN ; Jing TANG ; Jinxing WANG ; Qingguo LI ; Shui WANG
Publication Type:Journal Article
Keywords: Keratins; Breast neoplasms
From: Chinese Journal of General Practitioners 2009;8(12):906-908
CountryChina
Language:Chinese
Abstract: Expression of cytokeratin19(CK19)mRNA was detected by reverse transcription-PCR in bone marrow and integrin α_vβ_3 was detected by immunohistochemistry(IHC streptavidin-biotinperoxidase SP)in breast tissue from 62 breast cancer patients with negative axillary lymph nodes.Out of 62 patients 15cases(24%)presented positive CK19,in which all had positive integrin α_vβ_3;36 cases(58%)presented positive integrinα_vβ_3.Two markers were positively correlated with each other(kappa=0.6839,P＜0.05),and correlated with the size of tumor(P＜0.01).The results indicate that combined detection of CK19 in bone marrow and integrin α_vβ_3 in cancer tissues may be helpful for guiding therapy and estimating prognosis in breast cancer patients with negative axillary lymph nodes.