Viral dynamics during entecavtr therapy in patients with chronic hepatitis B
10.3760/cma.j.issn.1000-6680.2009.06.005
- VernacularTitle:慢性乙型肝炎恩替卡韦治疗过程中病毒动力学特点分析
- Author:
Bilian YAO
;
Xinxin ZHANG
;
Jing YANG
;
Demin YU
;
Donghua ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Antiviral agents;
Kinetics;
Models,theoretical;
Entecavir;
DNA,viral
- From:
Chinese Journal of Infectious Diseases
2009;27(6):338-342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the viral dynamics and clinical significance during the antiviral treatment by a mathematical model.Methods Six chronic hepatitis B patients were evaluated with a kinetic model(Neumann model)during dose of 0.5 mg/d oral entecavir.Blood samples were drawn for HBV DNA measurement at week 0,2,4,12,24.Non-linear modeling was used to fit individual patient data.Results The median effectiveness in blocking viral production was 99.970%(n=6).The median half-life of viral turn-over was 1.6 d(n=6).The median half-life of infected hepatocytes was 21.3 d(n=5).Compared with the other patients,the c(virions are cleared at a rate)、ε(effectiveness)、δ(infected cell are lost at a rate)value of one patient(eg.6)were all lower and the half-life of virus and infected cells were higher,and eg.6 developed viral break-through after 38 weeks of follow-up.Conclusions Viral load decay showed a biphasic pattern during entecavir therapy which can be described with a mathematical model.The model relates processes of viral infection and replication as well as drug efficacy to model parameters.It indicates the prediction of bio-mathematical model during antiviral treatment.
