The role of neuronal autophagy in hypoxic-ischemic brain injiny
10.3760/cma.j.issn.1673-4165.2009.12.011
- VernacularTitle:神经元自噬在缺血缺氧性脑损伤中的作用
- Author:
Qianyi HE
;
Guoping PENG
;
Benyan LUO
- Publication Type:Journal Article
- Keywords:
autophagy;
hypoxia-ischemia,brain;
neurons;
apoptosis;
necrosis
- From:
International Journal of Cerebrovascular Diseases
2009;17(12):940-943
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a metabolic pathway that widely presents in eukaryotic cells through the lysosomal mechanism to degrade its components. Autophagy regulates cell death not only by activating classic autophagosomal-lysosomal pathway, but also by influencing the occurrence and development of apoptosis and necrosis. Currently, the effect of autophagy in neuronal injury after acute cerebral ischemia/hypoxia and its specific mechanisms remain unclear. Studies have demonstrated that the autophagy after ischemia/hypoxia has a neuroprotective effect, such as maintaining neuronal homeostasis and reducing neuronal death; but other studies have also suggested that autophagy may aggravate neuronal injury after ischemia/hypoxia by activating multiple pathways, and even induce neuronal death.
