Immortalization of liver cells: experimental studies and application
10.3760/cma.j.issn.1007-8118.2010.02.027
- VernacularTitle:肝细胞永生化:实验研究与应用
- Author:
Hualian HANG
;
Xiaolei SHI
;
Yitao DING
- Publication Type:Journal Article
- Keywords:
Liver cells;
Immortalization;
Studies and application
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocyte is the core raw materials of bioartificial liver support system, primary hepatocyte is lim-ited to application because of short survival and difficult cul-ture in vitro. Porcine hepatocyte which has been used re-cently exist the risks of endogenous retrovirus transmission.With the development of molecular biology, it has been pos-sible that hepatocyte is immortalized recently. Immortalized hepatocytes have greatly significant to drug toxicology, bio-artificial liver support system and tissue engineering of liver.Therefore, we will review the prospects for research and ap-plication of immortalized hepatocytes.
