The protective mechanism of fructose-1,6-disphophate on the hypoxic-ischemic brain damage of neonatal rats
10.3760/cma.j.issn.1673-4408.2009.05.002
- VernacularTitle:1,6-二磷酸果糖对新生鼠缺氧缺血性脑损伤的保护机制研究
- Author:
Weichao LI
;
Guilan CHU
- Publication Type:Journal Article
- Keywords:
Fructose-1,6-disphophate;
Brain ischemia;
Brain hypoxic;
Rat
- From:
International Journal of Pediatrics
2009;36(5):446-447
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective mechanism of fructose-1, 6-disphophate on the hypoxic-ischemic brain damage of neonatal rats.Methods Seven-day-old Wistar rats were randomly divided into HIBD control group,saline-treated group, FDP-treated group. FDP-treated group was redivided into groups of high, middle and low dose.The expression of caspase-3mRNA was detected at 24h after HIBD with RT-PCR. Results There were no sifnificant differences of the caspase-3 mRNA expression among the saline-treated group, HIBD group and low dose FDP-treated group(P >0.05).The expressions of caspase-3 mRNA in the middle and high dose FDP-treated groups decreased significantly as campared to the above three groups (P < 0.05), but there was no significant difference between the two groups (P > 0.05). Conclusion The neuronal protective mechanism of FDP might be related to dewnregulate the gene expression of caspase-3 in brain tissue,and decrease the apoptosis of neuron after HIBD.
