The role of matrix metalioproteinase-9 and high sensitive C-reactive protein in type 2 diabetes mellitus combined with coronary heart disease
10.3760/cma.j.issn.1673-4904.2010.07.001
- VernacularTitle:2型糖尿病合并冠心病患者血清基质金属蛋白酶-9及高敏C反应蛋白水平的表达和临床意义
- Author:
Xingxing ZHANG
;
Wenjun WU
;
Zimiao CHEN
;
Xueli CAI
;
Dawang WANG
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase 9;
C-reactive protein;
Diabetes mellitus,type 2;
Coronary disease
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(7):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of matrix metalloproteinas-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) combined with coronary heart disease(CHD). Methods Thirty-one patients with T2DM combined with CHD(T2DM combined with CHD group) ,50 patients with CHD (CHD group) and 30 healthy volunteers (control group) were studied. Serum MMP-9 was measured by ELISA, and serum hs-CRP was measured by scattering immunoturbidimetric assay. Results The level of MMP-9 in T2DM combined with CHD group (409.62 μg/L) was significantly higher than that in CHD group (263.40 μg/L) and control group [(196.15 ±44.89) μg/L] (P < 0.05).The level of hs-CRP in T2DM combined with CHD group (17.20 mg/L) was significantly higher than that in CHD group (4.57 mg/L) and control group [(1.52±0.78) mg/L] (P <0.01). MMP-9 wa significantly related with hs-CRP in T2DM combined with C HD group (r = 0.482,P < 0.01). Conclusion The serum M MP-9 and hs-CRP levels are closely associated with the occurrence and development of diabetes related coronary atherosclerosis.
