Clinical significances of plasma cystatin C levels in patients with coronary artery diseases
10.3760/cma.j.issn.1671-0282.2010.03.013
- VernacularTitle:血浆胱抑素C对冠心病的临床预测价值
- Author:
Changjiang GE
;
Fang REN
;
Shuzheng Lü
;
Hong LIU
;
Xiantao SONG
;
Xin CHEN
;
Kang MENG
;
Xiaofan WU
;
Fei YUAN
;
Zening JIN
;
Hong LI
;
Fengqing JI
- Publication Type:Journal Article
- Keywords:
Cystatin C;
hs-CRP;
Coronary artery disease;
Acute coronary syndrome
- From:
Chinese Journal of Emergency Medicine
2010;19(3):273-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between plasma cystatin C concentration (PcyC) and coronary artery diseases (CAD). Method A total of 126 subjects with CAD evidenced by coronary angiography admitted from April 2007 to March 2009 were divided into three groups: stable angina pectoris (SAPs, n = 34),unstable angina pectoris (UAPs, n = 56) and acute myocardial infarction (AMIs, n = 36), according to the diag-nostic criteria of CAD set by WHO. Another 34 subjects without CAD were taken as controls. There were no statis-tical differences in demographics among four groups. Serum lipids profile, uric acid (UA), PcyC and high-sensi-tive C-reactive protein (hs-CRP) were determined. And in the meantime, all patients were followed up for six months and adverse cardiovascular events were recorded. Comparisons were made between groups with a number of independent-sample t -tests. Data were processed with analysis of variance to test the differences in means among four groups, and the means were compared with chi-square test. Statistical significance was established at a P val-ue of less than 0.05. Results Cystatin C levels were significantly higher in UAPs than that in SAPs and in controls (P < 0.05), but were much lower than that in AMIs (P < 0.05). And much higher concentration of hs-CRP was found in UAPs (P < 0.05) and in AMIs (P < 0.01). Cystatin C was positively and significantly corre-lated with age, hs-CRP, WBC, creatinine and UA (r > 0, P < 0.05), whereas a significantly negative correla-tion with high-density lipoprotein cholesterol was found (r = - 0.227, P < 0.05). These coefficients were obvi-ously high for creatinine (r = + 0. 612), and WBC (r = + 0.459). During the period of six-month follow-up, 26 patients with adverse cardiovascular events were found, and had significantly higher cystatin C levels than 22 con-trols at admission (P < 0.01). Conclusions Cystatin C plays a pivotal role in the course of CAD, and the PcyC is a strong predictor for the risk of cardiovascular events.
