Expression and clinical significance of Akt and phosphoryled Akt1 in pancreatic carcinoma
10.3760/cma.j.issn.1674-1935.2010.02.018
- VernacularTitle:Akt和磷酸化Akt1在胰腺癌组织中的表达及意义
- Author:
Jun LIU
;
Zhengjun QIU
;
Tao JIANG
;
Chen HUANG
;
Jing SUN
;
Hongcheng SUN
;
Fuquan ZHONG
;
Yubiao JIN
;
Honghui HU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Immunohistochemistry;
Protein kinases;
Akt;
p-Akt1;
Prognosis
- From:
Chinese Journal of Pancreatology
2010;10(2):128-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Akt and phosphoryled Akt (p-Akt1) protein in pancreatic carcinoma and to determine the clinical significance. Methods In 74 cases of pancreatic carcinoma and 10 cases of normal pancreatic tissue samples, the expression of Akt and p-Akt1 were detected by immunohistochemical method, and the its relationship with clinicopathologic characteristics and prognosis were analyzed. Results The positive expression rate of Akt and p-Akt1 in pancreatic carcinoma were 87.8% and 83.8% respectively, while there was no expression of Akt and p-Akt1 in normal pancreatic tissue, and the difference was statistically significant (p < 0.05). There was a positive correlation between the expression of Akt and p-Akt1 in pancreatic carcinoma (r =0.274, P =0. 018). The expression of Akt and p-Akt1 was not significantly associated with the age, sex, location, size, pathology stages, lymph nodes metastasis, clinical stages and nerve invasion of the tumor (P >0.05). But the higher expression of p-Akt1 was associated with T stages and TNM staging (p =0. 002). Patients with high intensity of Akt and p-Akt1 expression showed a significantly longer median survival time [(16.0 ± 5.7) month and (23.0 ± 5.5) month, respectively]than those with low intensity expression [(9.3 ± 0.2) month and (11.1 ± 1.8) month (P = 0. 007 and P = 0.004) respectively]. Conclusions p-Akt1 expression is a significant positive prognostic factor for pancreaticcarcinoma and detection of p-Akt1 expression may be of clinical value.
