The risk predictive value of high sensitivity C-reactive protein level for new hemorrhagic stroke events
10.3760/cma.j.issn.0578-1426.2010.06.005
- VernacularTitle:高敏C反应蛋白对新发脑出血风险的预测价值
- Author:
Jie ZHU
;
Shouling WU
;
Yanxiu WANG
;
Jianli WANG
;
Hongtao ZHAO
;
Guosheng HOU
;
Dongqing LI
;
Cheng JIN
;
Jinfeng LI
;
Yanrong DI
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
Cerebral hemorrhage;
Case-control study
- From:
Chinese Journal of Internal Medicine
2010;49(6):469-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk prediction for new intracerebral hemorrhage (ICH) with high sensitivity C-reactive protein ( hs-CRP) level. Methods In a retrospective, nested, case-controlled study, 323 cases of ICH were identified and matched with 646 controls. The hs-CRP levels at baseline were compared between the two groups. The relevance of different hs-CRP levels and the risk of ICH were analyzed. Results The ICH group had a higher median hs-CRP levels (1.10 mg/L) as compared with the control group (0. 66 mg/L) with significant difference ( P<0.01 ). In addition, the increase of risk associated with hs-CRP levels was primarily observed in the individuals with the highest quartile of hs-CRP levels(>2.12 mg/L). These patients had an increased risk of ICH (OR 2. 58, 95% CI 1. 77 to 3. 76) as compared with those in the lowest quartile(≤=0.30 mg/L). Individuals with basiline hs-CRP levels above the specified cut point of 3 mg/L ormore and those in the 80th percentile were at a markedly increased risk of ICH (for specified cut point of 3 mg/L,0R2.26, 95% CI 1.60-3.20, P<0.01; for 80th percentile, OR 2.24,95% CI 1.60-3.13, P <0.01, respectively). Conclusions Risk of ICH might be predicted with the level of hs-CRP. With the increase of hs-CRP level at baseline, the risk of ICH was increased.
