Liver transplantation for intrahepatic cholangiocarcinoma in 11 cases

VernacularTitle:单中心11例肝内胆管细胞癌肝移植疗效分析
Author: Tong ZAHNG ; Bingsheng FU ; Huimin YI ; Shuhong YI ; Chi XU ; Hua LI ; Jian ZHANG ; Genshu WANG ; Yang YANG ; Changjie CAI ; Minqiang LU ; Guihua CHEN
Publication Type:Journal Article
Keywords: Bile duet neoplasms; Liver transplantatiom; Survival rate
From: Chinese Journal of General Surgery 2010;25(6):469-471
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of liver transplantation(LT)on the prognosis in patients with intrahepatic cholangiocarcinoma(ICC).Methods A retrospective analysis was performed on 11 consecutive patients with ICC who underwent LT between October 2003 and November 2008 at our institution.The overall and disease-free survival rates were calculated by the Kaplan-Mayer method.Results The median survival time Was 9.0 months(2.5-53 months).The 1-,2-,3-and 4-year disease-free survival rate and overall survival rate of all the patients were 51.9%、51.9%、51.9%、51.9%and 50.5%、50.5%、50.5%、50.5%,respectively.The perioperative mortality and the recurrence rate were 0 and 43.5%,respectively.The survival rate and disease-free survival time of patients with recurrence were 2.5-10 months(mean 7.5 months)and 1-8 months(mean 3.8 months).Conclusions The prognosis of LT for ICC is rather poor.ICC patients with lymph node metastasis.vascular or bile duct invasion is contraindicated for LT.