Placental alpha-microglobulin-1 in vagina liquid to diagnose premature rupture of membranes
10.3760/cma.j.issn.1673-4904.2010.15.002
- VernacularTitle:检测阴道液中胎盘α微球蛋白-1诊断胎膜早破的价值
- Author:
Guangling GUO
;
Yongzhen LIU
;
Chunlian ZHANG
;
Zhentong WEI
;
Shuangyun CHEN
- Publication Type:Journal Article
- Keywords:
Placenta;
Fetal membranes,premature rupture;
Diagnosis;
Alpha-microglobulin-1
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(15):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of placental alpha-microglobulin-1 in vagina liquid to diagnose premature rupture of membranes. Methods A prospective observational study to initial evaluation included both the standard clinical evaluation for rupture of membranes and placental alpha-microglobulin-1 immunoassay. Rupture of membranes was diagnosed if fluid was seen leaking from the cervical os or if two of the following three conditions were present: pooling of fluid, positive nitrazine test, or feming. Rupture of membranes was diagnosed definitively on review of the medical records after delivery. Results Placental alpha-microglobulin-1 immunoassay confirmed rupture of membranes at initial presentation with a sensitivity of 100% (89/89), specificity of 91% (10/11), positive predictive value of 99% (89/90), and negative predictive value of 100% (10/10),false positive rate of 9% (1/11). Placental alpha-nricroglobulin-1 immunoassay was better than the conventional clinical assessment in confirming the diagnosis of rupture ofmembranes (P<0.01). Conclusion Measurement of placental alpha-microglobulin-1 in cervicovaginal secretions is superior to conventional clinical assessment in the diagnosis of rupture of membranes.
