Expression of cyclooxygenase-2 and epidermal growth factor receptor in astrocytomas and its clinical significance
10.3760/cma.j.issn.1008-1372.2010.02.014
- VernacularTitle:环氧化酶-2和表皮生长因子受体在星形细胞瘤中表达的意义
- Author:
Hongtao ZHANG
;
Miao TIAN
;
Chunming XIU
;
Jie LIU
;
Guangqiang CUI
;
Yunbo WANG
;
Shumao PAN
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase 2/ME;
Receptor,epidermal growth factor/ME;
Astrocytoma/ME
- From:
Journal of Chinese Physician
2010;12(2):185-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) in astrecytomas, as well as the correlation between them. Methods The expression of COX-2, EGFR and PCNA were respectively detected by immunohistochmical (S-P) method in 68 astrocytomas and 5 cases normal brain tissue. Proliferation index (PI) was calculated and the correlation of COX-2, EGFR and PI was analyzed. Results COX-2 and EGFR were negative expression in normal brain tissue. The positive expression rate of COX-2 and EGFR in high grade astrocytomas was significantly higher than that in low grade astrocytomas(73.53% vs 44. 18% ,67.65% vs 38.24%, P <0. 01 ), and the PI was significantly higher than that in low grade astrocytumas as well as normal brain tissue(46.11 ± 10. 68vs 23. 04±6. 25,4. 52±0. 95, P <0. 01 ). The PI in COX-2 positive group was higher than that in negative group( P <0. 01 ). The positive expression rate of COX-2 in the group with EGFR positive expression was higher than that in the negative group. Conclusions The expression of COX-2 and EGFR was related to pathological feature of astrocytomas. COX-2 may promote the proliferation of tumor cells. There was a static correlation between the expression of EGFR and COX-2 in astrocytomas. EGFR signal transduction probably modulated the expression of COX-2 in astrocytomas cells.
