The significance and expression of CD147 and NF-κB in esophageal squamous cell carcinoma

VernacularTitle:CD147、NF-κB在食管鳞状细胞癌组织中的表达及意义
Author: Lina XIONG ; Zhifan XIONG ; Yan TU
Publication Type:Journal Article
Keywords: Antigens,CD147/ME; NF-kappa B/ME; Esophageal neoplasms/ME; Carcinoma,squamous cell/ME
From: Journal of Chinese Physician 2010;12(9):1171-1173
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of extracellular matrix metalloproteinase inducer (CD147), nuclear factor kappa B (NF-κB) in esophageal squamous cell carcinoma tissue and probe their relationship to invasion and metastasis of esophageal carcinoma. Methods Immunochemical staining was performed to detect the expression of CD147 and NF-κB protein in 40 cases of esophageal carcinoma tissues and 40 cases of normal control. Results The positive rate of CD147 and NF-κB in esophageal carcinoma tissues and in adjacent noncancerous tissues were 77.5%/87.5% Vs 25%/42. 5%, P＜0.05.The positive rate of their prophase and metaphase-advanced stage esophageal carcinoma tissues were 33.3%/90.3% Vs 55.6%/96.8%, P＜0.05..The positive rate of non-metastatic and metastatic esophageal carcinoma tissues were 28.6%/87.9% Vs 42.9%/97%, P＜0.05.Conclusions Our results suggested that the increased expression of CD147 and NF-κB contributed to tumor angiogenesis in esophageal squamous cell carcinoma, which might be through the common pathway.