Autophagy and its role in colorectal pathogenesis and treatment
10.3760/cma.j.issn.1673-422X.2010.10.018
- VernacularTitle:自噬及其与结直肠癌的发生和治疗
- Author:
Guifang GUO
;
Liangping XIA
- Publication Type:Journal Article
- Keywords:
Autophagy;
Colorectal neoplasms
- From:
Journal of International Oncology
2010;37(10):774-777
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a catabolic process involving the degradation of a cell's own proteins and organelles and the subsequent recycle of cellular products. Despite the fact that autophagy helps maintain survival, excessive autophagy can lead to autophagic cell death. Recent researches showed that autophagy played an important role in the development, progression and treatment of colorectal cancer;however, the exact mechanisms of autophagy and its effect on chemotherapy and radiotherapy are still under debate.
