A study on the effects of PPARγ ligand rosiglitazone in the growth of MGC803 cells transplanted into subrenal-capsule of mice
- VernacularTitle:罗格列酮对MGC803细胞小鼠肾囊膜下移植瘤生长的影响
- Author:
Lihui ZHU
;
Li ZHANG
;
Dazhi ZHONG
- Publication Type:Journal Article
- Keywords:
PPAR gamma;
Stomach neoplasms;
MGC803;
Neoplasm transplantation;
Growth;
Inhibition
- From:
Cancer Research and Clinic
2008;20(3):155-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitory effects of PPARγ ligand rosiglitazone in vivo of mice which were transplanted the human gastric carcinoma cells line MGC803 into subrenal-capsule.Methods To establish kunming mouse tumor modles of MGC803 cells transplanted into subrenal-capsule and assay the inhibiting growth effects of 50 mg／kg rosiglitazone which were continuously poured into mice gastric for five days by the dissect microscope and HE stain.Results Rosiglitazone could inhibit the growth of MGC803 cells transplanted into subrenal-capsule of mice in vivo by inhibiting proliferation and inducting apoptosis,the tumor inhibitory rate was 62.9％.Conclusion PPARγ ligand rosiglitazone can inhibit the growth of MGC803 cells transplanted into subrenal-capsule of mice in vivo.
