Serum osteocalcin in patients with spinal cord injury
- VernacularTitle:脊髓损伤患者血清骨钙素变化的临床研究
- Author:
Ying ZHENG
;
Shurong JI
;
Hongjun ZHOU
;
Genlin LIU
;
Chunxia HAO
;
Lidong PAN
- Publication Type:Journal Article
- Keywords:
Osteocalcin;
Spinal cord injury;
Bone metabolism
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(5):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the time course of disease and bone metabolism changes in patients with spinal cord injury. Methods Data on serum osteocalcin(SO)measured by radioimmunoassay(RIA)from a database on 167 patients with spinal cord injury(SCI)were analyzed retrospectively.The patients were divided into four groups according to the time post-injury:group A(＜3 months post-injury,n=44),group B(3-6 months post-injury,n=42),group C(7-12 months post-injury,n=37)and group D(＞12 months post-injury,n=44). Results The mean SO value in all 4 groups of patients was significantly higher than normal.The mean SO value of group B was significantly higher than that of group A,but not significantly different from that of group C.The mean SO value of group D was significantly lower than that of group C,but not significantly different from that of group A.Conclusion Serum osteocalcin is elevated in the early stages of SCI,and its subsequent de-cline is closely correlated with the time post-injury.
