Sulodexide-induced Hyperkalemia: A Case Report.
- Author:
In Il PARK
1
;
Myung Jin CHOI
;
Jong Woo YOON
;
Young Ki LEE
;
Sung Gyun KIM
;
Ji Eun OH
;
Jang Won SEO
;
Hyung Jik KIM
;
Jung Woo NOH
;
Ja Ryong KOO
Author Information
1. Division of Nephrology, Department of Internal Medicine, College of Medicine Hallym Kidney Research Institute, Hallym University, Chuncheon, Korea. jrkoo@hallym.ac.kr
- Publication Type:Case Report
- Keywords:
Sulodexide;
Hyperkalemia;
Diabetic nephropathy
- MeSH:
Dermatan Sulfate;
Diabetic Nephropathies;
Furosemide;
Glycosaminoglycans;
Heparin;
Humans;
Hyperkalemia;
Hypertension;
Losartan;
Middle Aged;
Polystyrenes
- From:Korean Journal of Nephrology
2009;28(3):227-229
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sulodexide is composed of two glycosaminoglycans (fast-moving heparin 80%, dermatan sulfate 20%) that are capable of preventing diabetic nephropathy by correcting abnormal glycosaminoglycan metabolism. Considering heparin-like propertyof sulodexide, side effect profiles of sulodexide are expected to be similar with those of heparin. Among those side effects, we remarked on heparin-induced hyperkalemia and hereby report a case of severe hyperkalemia during the use of sulodexide. A 52-year-old man with diabetic nephroapthy and hypertension was admitted to our hospital because of severe hyperkalemia up to 7.5 meq/L. His clinical condition was stable and medications including losartan and furosemide had not been changed for last 6 months except the addition of sulodexide, which was started 30 days prior to admission. Despite intensive use of Kayexalate and immediate discontinuation of losartan, hyperkalemia aggravated up to 8.0 meq/L. After recognition of possible sulodexide-induced hyperkalemia, sulodexide was discontinued, which resulted in rapid correction of hyperkalemia. In view of the above discussed clinical consideration, we suspect sulodexide as a major cause of hyperkalmia and report this case with a review of literature.
