A randomized controlled multicenter trial of Rebamipide on chronic non-atrophic gastritis
- VernacularTitle:瑞巴派特治疗慢性非萎缩性胃炎的随机、对照、多中心临床研究
- Author:
Yiqi DU
;
Zhaoshen LI
;
Xianbao ZHAN
;
Duowu ZOU
;
Jie CHEN
;
Yanfang GONG
;
Jianlin REN
;
Liping HE
;
Zhijian ZHANG
;
Xiaozhong GUO
;
Jianshen WU
;
Zibin TIAN
;
Ruihua SHI
;
Bo JIANG
;
Dianchun FANG
;
Youming LI
- Publication Type:Journal Article
- Keywords:
Rebamipide;
Chronic non-atrophic gastritis;
Helieobacter pylori
- From:
Chinese Journal of Digestive Endoscopy
2008;25(7):353-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of rebamipide on chronic non-atrophic gastritis (NAG) with erosion and its protection of gastric mucosa from Helicobacter priori(Hp) associated lesions.Methods Patients(n=452)with endoscopically confirmed NAG with erosion from 11 hospitals in China were enrolled and randomly assigned at a ratio of 3:1 to receive either rebamipide(100 mg t.i.d.)or sucralfate(1.0 t.i.d.)for 8 weeks.Hp infected patients received eradication treatment before randomization.Symptoms,endoscopic scores and histological changes were recorded before and after therapy.Concentrations of serum prostaglandin E(PGE:)and oxygen free radical(MDA)were measured in patients from 2 centers.Results Per-protocol analysis(n=415)showed that the dyspeptic symptom score in rebamipide group decreased significantly after eight weeks of treatment. The endoscopic inflammation score in rebamipide group also decreased from 2.65 ±0.09 to 0.60±0.10(P<0.001),which was,significantly better than that of sucralfate group(P<0.001).Histological findings were consistent with the endoscopic findings.There Was a significant elevation(P=0.002)in PGE2 concentration in mucesa from rebamipide-treated subjects [(225.4±18.3) pg/g vs.(266.7±14.7)Pg/g] compared with that in sucralfate group.The concentration of MDA significantly decreased from(325.9±65.6)mmoL/g to(216.5±61.5)mmol/g,which is markedly different from that of sucralfate group(P=0.046).No statistical difference was found between Hp eradication group,Hp infection group and Hp negative group,regarding the effect of Rebamipide.Conclusion Compared to sucralfate,Rebamipide demonstrates a superior effect on improvement of dyspepsia symptom and endoscopic findings in erosive NAG,which is not influenced by Hp infection.
