Expression of CD38 in T cells of chronic lymphocytic leukemia
- VernacularTitle:分化抗原簇CD38在慢性淋巴细胞白血病T淋巴细胞中的表达研究
- Author:
Yujie WU
;
Jianyong LI
;
Lei FAN
;
Sujiang ZHANG
;
Hongxia QIU
;
Wei XU
- Publication Type:Journal Article
- Keywords:
Leukemia,T-cell,chronic;
T lymphocytes;
Antigens,CD38
- From:
Chinese Journal of Laboratory Medicine
2008;31(10):1153-1156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the CD38 expression in T-cens(CD38-T)of chronic lymphocytic leukemia(CLL).Methods Multi-parameter flow cytometry was used to detect the expression of CD38,ZAP-70 and CD4/CD8 in 83 CLL patients.Results CD38 was positively expressed in 49.4%(41/83)T-cells(CD38-T)and 50.6%(42/83)tumor cells(CD38-B)of all CLL patients.The expression of the CD38-T was highly correlated with CD38-B(r=0.553,P＜0.01).ZAP-70+CD38+-T and ZAP-70-CD38-T constituted 67.5%(56/83)of CLL patients.There was significant correlation between CD38-T and ZAP-70 (r=0.349,P＜0.01).There was 33.3%(14/42)patients with CD38-T in Binet A patients,and 65.9% (27/41)in Binet B+C patients.There was also significant correlation between CD38-T and Binet B+C(r=0.312,P＜0.05),and CD4/CD8(r=0.453,P＜0.05).Conclusions Aberrant expression of CD38 in T-cells might be of prognostic relevance in CLL Most of the patients with high level CD38-T expression are accompanied with disorder or imbalance of immune function.CD38 expression in T cells might be a new prognostic factor in CLL.
