The expression of P-selectin in rats with hepatic ischemia reperfusion injury
10.3760/cma.j.issn.1008-6706.2011.01.020
- VernacularTitle:肝缺血再灌注损伤大鼠P-选择素的表达
- Author:
Baobao DANG
;
Jin DANG
;
Xiaomei CHU
- Publication Type:Journal Article
- Keywords:
Reperfusion injury;
P-selectin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the express of P-selectin in liver-tissue,on the model of HIRI in rats,we explored the pathogenesy of HIRI. Methods 32 female Sprague-Dawley rats were divided into four groups randomly ( n = 8 in each group): sham operation group ( group SO ), ischemia 30 min without repe- rfusion group ( group Ⅰ),30 min reperfusion following ischemia 30 min group ( group IR30 min), one hour reperfusion following ischemia 30min group( group IR1h). The model of HIRI was maded by Pringle's hepatic vascular occlusion. The contents of P-selectin in hepatic tissue were measured by kit of SP. Results After ischemia 30 min,the content of P-selectin in hepatic tissue increased less obviously than group SO; After 1 h reperfusion, the content of P-selectin in hepatic tissue vascular endothelial and hepatocyte express more broadly than group SO. Conclusion The content of P-selectin in hepatic tissue was increased gradually in the process of hepatic ischemia reperfusion injury(HIRI) in rats.
