Effects of Botulinum Toxin A Injection into Salivary Glands of Patients with Brain Lesion Suffering from Posterior Drooling.
- Author:
Zee Ihn LEE
1
;
Dong Hwi PARK
;
Dong Hyun JO
;
Won Duck CHOI
;
Seung Deuk BYUN
Author Information
- Publication Type:Original Article
- Keywords: botulinum toxin type A; drooling; salivary glands
- MeSH: Botulinum Toxins; Botulinum Toxins, Type A; Brain; Cerebral Palsy; Humans; Hypoxia-Ischemia, Brain; Pneumonia, Aspiration; Salivary Glands; Sialorrhea; Sorbitol; Stress, Psychological; Tyramine; Weights and Measures
- From:Brain & Neurorehabilitation 2011;4(2):121-125
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The aim of the study was to evaluate the effectiveness of ultrasouond-guided salivary gland injection of botulinum toxin A (BTX-A) for posterior drooling. METHOD: 11 patients with brain lesion (9 cerebral palsy, 1 hypoxic ischemic encephalopathy and 1 mental retardation) with posterior drooling (an initial PDAS score greater than 2) and related pulmonary problems were recruited. Drooling severity was measured at baseline, 4 weeks, 3 months and 6 months after botulinum toxin A injection, by using Teacher Drooling Scale (TDS), Visual Analogue Scales (VAS), Drooling Score System (DSS)-severity, frequency and Posterior Drooling/Aspiration System (PDAS). RESULTS: The TDS, DSS-severity, DSS-frequency, VAS, PDAS were significantly reduced at 4 weeks and 3 months after BTX-A injection into salivary glands compared to pre-injection (p<0.05). However, there were no significant changes at 6 months compared to pre-injection level. CONCLUSION: BTX-A injection into salivary glands may improve anterior drooling in patients with brain lesions. Furthermore BTX-A injection into salivary glands may also decrease the posterior drooling which might related to respiratory symptoms in aspiration pneumonia.
