Implication of plasma pentraxin 3 in peripheral arterial disease of hemodialysis patients
10.3760/cma.j.issn.1001-7097.2009.11.001
- VernacularTitle:血浆五聚素3水平在血液透析患者外周动脉疾病中的意义
- Author:
Yijun ZHOU
;
Zhaohui NI
;
Jiwei ZHANG
;
Weiming ZHANG
;
Leyi GU
;
Qingwei WU
;
Guijuan SHEN
;
Yongmei WANG
;
Jiaqi QIAN
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
C-reactive protein;
Pentraxin 3 protein;
Peripheral vascular diseases;
Ankle brachial index
- From:
Chinese Journal of Nephrology
2009;25(11):821-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the role of pentraxin 3 (PTX3) in the development of peripheral arterial disease (PAD) in maintenance hemodialysis (MHD) patients. Methods One hundred and sixteen patients undergone MHD therapy in our center for more than 3 months were enrolled in the study. Clinical data were collected for analysis. Ankle-brachial index (ABI) was used to estimate the presence of PAD. Patients were divided into PAD group (ABI<0.9) and nonestimate the association of PAD with PTX3 as well as other potential risk factors. Results The incidence of PAD was 18.1% (21/116). Plasma level of PTX3 was significantly higher in PAD patients than that in non-PAD patients [(5.55 ±2.63) μg/L vs (2.32 ±1.29)μg/L, P<0.01].Univariate analysis showed ABI values were negatively correlated with plasma PTX3 levels (r =-0.548, P<0.01), high-sensitivity C-reactive protein (hsCRP), age, blood glucose and triglyceride. ROC curve of PAD revealed that area under curve (AUC) of PTX3 was 0.901 (P<0.01). With the cut-off value of PTX3 as 4.06 μg/L, the diagnostic sensitivity and specificity in PAD were 81.0% and 91.5%. ROC curve of PAD showed that AUC of hsCRP was 0.640 (P<0.05). With the cut-off value of hsCRP as 3.33 mg/L, the diagnostic sensitivity and specificity in PAD were 57.1% and 56.8%. Using Logistic regression, plasma PTX3 was found to be associated with PAD (0R=9.755, 95%CI:2.359-19.354, P=0.001). Conclusions The PAD incidence of MHD patients in our center is 18.1%. Plasma PTX3 level is significantly correlated with the presence of PAD in MHD patients. The sensitivity and specificity of PTX3 are higher than those of hsCRP for PAD diagnosis.
