Tapenatadol Induced Hyperactive Delirium: Report of One Case Successfully Managed with Opioid-switching
10.2512/jspm.11.525
- VernacularTitle:タペンタドール誘発性過活動型せん妄にオピオイドスイッチングが有効だった1例
- Author:
Takefumi Nishimoto
;
Megumi Hirooka
;
Reiko Bukawa
;
Hiroki Kodaira
;
Tetsuya Takahashi
;
Runa Shimada
;
Ikuo Gomyo
- Publication Type:Journal Article
- Keywords:
tapentadol;
delirium;
opioid-switching;
noradrenaline reuptake inhibitor
- From:Palliative Care Research
2016;11(2):525-528
- CountryJapan
- Language:Japanese
-
Abstract:
Introduction: This report describes a case of hyperactive delirium induced by tapenatadol whose symptoms were successfully managed with opioid-switching to oxycodon. Case: A 67-year-old female, who had been treated with chemotherapy for malignant thymoma, had to stop chemotherapy because of her carcinomatous pericarditis. Tapentadol 200 mg per day was administrated for her unbearable chest wall tumor invasion-related somatic pain. After a while, insomnia, visual hallucination, thought disturbance, and attention disturbance were appeared. We diagnosed as hyperactive delirium. Because her somatic pain was favorably controlled by tapentadol, we additionally administered quetiapine 50 mg per day instead of replacing tapentadol. Unfortunately, quetiapine was not effective for the delirium. We therefore switched opioids from tapentadol to oxycodon. The delirium was remitted soon after the switching without relapsing of the pain. Conclusion: Tapentadaol reportedly induce hyperactive delirium via its noradrenaline reuptake inhibitory action. This case suggests that switching tapenatadol to other opioid could be an effective option for opioid induced delirium.
