Three Cases of Coronary Artery Disease Associated with Hereditary Protein S Deficiency
10.4326/jjcvs.44.354
- VernacularTitle:冠動脈疾患を伴う先天性プロテイン S 欠乏症3例の経験
- Author:
Masamichi Ito
;
Yasuhiro Kamikubo
;
Makoto Takahira
- Publication Type:Journal Article
- Keywords:
hereditary protein S deficiency;
coronary artery disease;
coronary artery bypass grafting
- From:Japanese Journal of Cardiovascular Surgery
2015;44(6):354-357
- CountryJapan
- Language:Japanese
-
Abstract:
We encountered 3 cases of protein S deficiency accompanied by coronary artery disease (CAD). None of the patients had been given diagnoses of congenital protein S deficiency prior to referral to our department. Our examination revealed three-vessel CAD with distal lesions. CAD was of early onset in two patients in their 40 s. In 2 of the 3 patients, off-pump coronary artery bypass was performed, and continuous heparin infusion was postoperatively changed to oral warfarin. These patients had a favorable postoperative course and graft patency was maintained. In the third patient, who underwent repeated percutaneous coronary revascularization, in whom coronary artery bypass was contraindicated, oral warfarin alleviated the symptoms of CAD. No disease progression was observed in coronary angiography performed at the one-year follow-up examination.
