A Case of Wegener's Granulomatosis: Effect of Combination Therapy with Trimethoprim-Sulfamethoxazole and Prednisone.
10.2185/jjrm.43.987
- Author:
Tomio KAMETANI
;
Takeyuki HORIGAMI
;
Bunji KAKU
;
Tatsushi MORITA
;
Isao TANAKA
;
Yutaka IGARASHI
;
Hideo KOSHIDA
;
Tadayuki NAGAI
;
Masayuki KATO
;
Kenzo IKEDA
- Publication Type:Journal Article
- Keywords:
Wegener's granulomatiosis;
Trimethoprim-sulfamethoxazole;
Prednisone
- From:Journal of the Japanese Association of Rural Medicine
1994;43(4):987-990
- CountryJapan
- Language:English
-
Abstract:
This report concerns a 62-year-old woman with Wegener's granulomatosis. She complained cough, macroscopic hematuria and oligulia. She had a consolidation without a cavity in the left upper lung field, massive proteinuria (2.5 g/day) and massive hematuria. The serum creatinine level was 2.5 mg/dl. The C-ANCA was positive. Renal biopsy revealed crescentic glomerulonephritis. She wa treated with prednisone and trimethoprim-sulfamethoxazole. The lung shadow, proteinuria and hematuria disappeared in one month. The C-ANCA titer also decreased. The use of trimethoprimsulfamethoxazole which may eliminate an infection as a cause to promote Wegener's granulomatosis should be actively included in the conventional treatment.
