Anti-inflammatory Treatments and Serum Selectin Levels in Osteoarthritis
- Author:
Simona BELLOMETTI
;
Ute BAUER
;
Lauro GALZIANA
;
Yuko AGISHI
- Publication Type:Journal Article
- Keywords:
Osteoarthritis;
selectins;
inflammation;
joints;
anti-inflammatory therapies
- From:The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine
2003;66(4):249-258
- CountryJapan
- Language:English
-
Abstract:
Background: Osteoarthritis (OA) is an important rheumatic condition accompanied by synovial inflammation. Numerous leucocytes are recruited and their migration to the inflamed arthritic joints is mediated by adhesion molecules such as E-, P-, and L-selectins. We measured the serum selectin values in OA patients undergoing Mud Pack Treatment (MPT) or treated with anti-inflammatory drugs to test whether the effect of the treatments may be monitored by the level of serum selectins.
Materials and Methods: 50 OA patients were randomly divided into Group A (30 patients undergoing MPT) and Group B (20 patients receving 50mg diclofenac twice daily p. o.). Blood samples were collected from both groups before and after the treatments to test serum E-, P-, and L-selectin by ELISA methods.
Results: In Group B sE-selectin level showed a significant increment after the drug assumption. In Group A, a significant increment of sL-selectin after MPT was evident, while sP-selectin level did not present any significant variation.
Discussion: The study indicates that MPT and diclofenac are able to influence different adhesion molecules in OA patients. The combination of these two treatments may constitute a safe and effective anti-inflammatory therapy in rheumatic diseases.
