Effect of exercise training on heat-shock response in strenuous exercise.
- VernacularTitle:激運動に対する熱ショック応答に及ぼす運動トレーニングの効果
- Author:
NORIYUKI YABUNAKA
;
YOSHINORI OHTSUKA
;
ICHIRO WATANABE
;
HIROSHI NORO
;
HIROYUKI FUJISAWA
;
YUKO AGISHI
- Publication Type:Journal Article
- Keywords:
heat-shock proteins;
HSP 70;
exercise training;
rectal temperature;
skin temperature
- From:Japanese Journal of Physical Fitness and Sports Medicine
1994;43(5):399-405
- CountryJapan
- Language:Japanese
-
Abstract:
This study was conducted to examine the effect of exercise training on heat-shock response, the protective response to heat, oxidative stress and other stresses characterized by elevated synthesis of heat-shock proteins (HSP), in strenuous exercise. Five untrained men (aged 20-21 ) participated in the study. The protocol included strenuous exercise to exhaustion by bicycle ergometer (1 st Ex), 4 weeks of training (a 2 km run three days per week) and a repetition of the strenuous exercise (2 nd Ex) . We measured VO2 and VCO2 with a respiratorygas analyzer, 70 kDa heat-shock protein (HSP 70) of mononuclear cells by western blotting, and rectal and mean skin temperatures by thermistors during the strenuous exercise. After 4 weeks of training, VO2max was increased significantly (p<0.05) . HSP 70 increased immediately after the exercise in 3 of 5 subjects in the 1 st Ex, but not in the 2 nd Ex. Rectal temperatures rose significantly after both the 1 st and 2 nd Ex (p<0.05) . Mean skin temperatures fell significantly after both the 1 st and 2 nd Ex (p<0.05) . There was no correlation between rectal and mean skin temperatures and HSP 70. We observed the heat-shock response during strenuous exercise and the attenuation of this response after 4 weeks of exercise training. These results suggest that exercise training may have suppressive effects on the heat-shock response during strenuous exercise.
